A devastating explosion at a cafe in central Damascus' al-Marjah district has claimed the lives of at least five individuals and left 16 others injured, according to Syria's Ministry of Health. The blast occurred around 3:24pm local time (12:24 GMT) on al-Nasser Street, near the Palace of Justice. Syrian state media reported that the cause of the explosion was an explosive device. Authorities have launched an investigation into the incident, fearing a possible secondary explosion due to security concerns in the area. The site of the blast shows severe damage, with blood smeared on the floor. The bustling neighborhood has recently been hosting high-profile trials for former regime members at the nearby Ministry of Justice. Residents and Syrian security forces are providing first aid to the injured until ambulances arrive at the scene.